Article
Determination of the subunit stoichiometry of a voltage-activated potassium channel.
Nature - 21 Mar 1991
MacKinnon R
Abstract excerpt
The voltage-activated K+, Na+ and Ca2+ channels are responsible for the generation and propagation of electrical signals in cell membranes. The K+ channels are multimeric membrane proteins formed by the aggregation of an unknown number of independent subunits. By studying the interaction of a scorpion toxin with coexpressed wild-type and toxin-insensitive mutant Shaker K+ channels, the subunit stoichiometry can...
Topics
- Animals
- Charybdotoxin
- Membrane Potentials
- Membrane Proteins
- Mutation
- Potassium Channels
- RNA
- Scorpion Venoms
- Xenopus