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Article

A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing.

Chemical communications (Cambridge, England) - 30 Jun 2016

He Zhiyong, Chen Yuqi, Wang Yafen, Wang Jiaqi, Mo Jing, Fu Boshi, Wang Zijing, Du Yuhao, Zhou Xiang

Abstract excerpt

A new DNA building block (d(Tet)U) bearing a tetrazole and allyloxy group at N-phenyl ring linked through an aminopropynyl linker to the 5-position of 2'-deoxyuridine was synthesized. The modified DNA can be lit up via a photoinduced intramolecular tetrazole-alkene cycloaddition reaction, but quenched when the fully-matched double strand is formed. This conspicuous difference in fluorescence could open a door for...

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PMID: 27315545
DOI: 10.1039/c6cc03098j

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