Article
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer.
Journal of medical virology - 1 Apr 2011
Chatterjee Koushik, Williamson Anna-Lise, Hoffman Margaret, Dandara Collet
Abstract excerpt
Only a small fraction of women infected with human papillomavirus (HPV) progress to cervical cancer pointing to additional risk factors including host genetics that might play a role in development of cervical cancer. Caspase-8 (encoded by CASP8 gene) is crucial in generating cell death signals to eliminate potentially malignant cells. Genetic variation in CASP8 might influence the susceptibility to cancer. CASP8...
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