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Article

A newly discovered role of telomeres in an ancient organism.

Nucleus (Austin, Tex.) - 1 Jan 2000

Li Bibo

Abstract excerpt

Trypanosoma brucei expresses Variant Surface Glycoprotein (VSG) genes in a strictly monoallelic fashion in its mammalian hosts, and the regulation of this important virulence mechanism has been the research focus for decades. Telomere position effect (TPE), an epigenetic phenomenon, has been proposed to play a critical role in VSG regulation, yet no telomeric protein was identified whose disruption led to VSG...

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Share to Chromatin Assembly and Disassembly
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21327073
DOI: 10.4161/nucl.1.3.11742
PMCID: PMC3027032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A newly discovered role of telomeres in an ancient organism.PMID 21327073Read ↗

TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomesSemantic proximity Read ↗

Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomesSemantic proximity Read ↗

[The telomere position effect: silence in the back row!].Semantic proximity Read ↗

Epigenetics and transcriptional control in African trypanosomes.Semantic proximity Read ↗

Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybridsSemantic proximity Read ↗

The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expressionSemantic proximity Read ↗

T rypanosoma brucei Orc 1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switchingSemantic proximity Read ↗

Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changesSemantic proximity Read ↗

Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrestSemantic proximity Read ↗

Telomere maintenance in African trypanosomesSemantic proximity Read ↗

The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolenseSemantic proximity Read ↗

African trypanosomes: the genome and adaptations for immune evasionSemantic proximity Read ↗

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