Article
Role of non-HLA genetic polymorphisms in graft-versus-host disease after haematopoietic stem cell transplantation.
International journal of immunogenetics - 1 Oct 2006
Bertinetto F E, Dall'Omo A M, Mazzola G A, Rendine S, Berrino M, Bertola L, Magistroni P, Caropreso P, Falda M, Locatelli F, Busca A, Amoroso A
Abstract excerpt
Graft-versus-host disease (GvHD) is the main complication after haematopoietic stem cells transplantation (HSCT) and acute forms (aGvHD) occur in 20-40% of cases even after donor (D) and recipient (R) HLA matching, apparently because of D/R minor histocompatibility antigen (mHA) mismatches and cytokine polymorphisms. The genotype of cytokines and mHA of 77 haematological R following HSCT from HLA identical...
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