Article
Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.
American journal of physiology. Cell physiology - 1 May 2011
Deb Tushar B, Zuo Annie H, Wang Youhong, Barndt Robert J, Cheema Amrita K, Sengupta Surojeet, Coticchia Christine M, Johnson Michael D
Abstract excerpt
We have recently described a novel role for pregnancy-upregulated non-ubiquitous calmodulin kinase (Pnck) in the induction of ligand-independent epidermal growth factor receptor (EGFR) degradation (Deb TB, Coticchia CM, Barndt R, Zuo H, Dickson RB, and Johnson MD. Am J Physiol Cell Physiol 295: C365-C377, 2008). In the current communication, we explore the probable mechanism by which Pnck induces...
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