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Article

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration.

Journal of cell science - 15 May 2009

Woodley David T, Fan Jianhua, Cheng Chieh-Fang, Li Yong, Chen Mei, Bu Guojun, Li Wei

Abstract excerpt

Hypoxia is a microenvironmental stress in many pathological conditions, including wound healing and tumor invasion. Under hypoxia, the cells are forced to adapt alternative and self-supporting mechanisms. Understanding these mechanisms may lead to new insights into human disorders. We report here a novel autocrine signaling mechanism by which hypoxia promotes human keratinocyte (HK) migration. First, hypoxia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HSP90 Heat-Shock Proteins

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

Open in PubMed Open full text

Identifiers

PMID: 19383717
DOI: 10.1242/jcs.047894
PMCID: PMC2680098

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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