Article
Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal.
Biochemical and biophysical research communications - 19 Oct 2007
Nakatani Yoshihito, Hokonohara Yutaka, Kakuta Shigeru, Sudo Katsuko, Iwakura Yoichiro, Kudo Ichiro
Abstract excerpt
Cytosolic prostaglandin (PG) E synthase (cPGES) is constitutively expressed in various cells and regulates cyclooxygenase (COX)-1-dependent immediate PGE(2) generation. Its primary structure is identical to co-chaperone p23, a heat shock protein 90 (Hsp90)-binding protein. We have revealed that Hsp90 regulated both cPGES/p23 and its client protein kinase CK2. In this study, in order to examine the role of...
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