Article
The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation.
The Journal of biological chemistry - 8 Mar 2002
Grammatikakis Nicholas, Vultur Adina, Ramana Chilakamarti V, Siganou Aliki, Schweinfest Clifford W, Watson Dennis K, Raptis Leda
Abstract excerpt
The 90-kDa heat shock protein (Hsp90), the target of the ansamycin class of anti-cancer drugs, is required for the conformational activation of a specific group of signal transducers, including Raf-1. In this report we have identified a 75-kDa Raf-associated protein as Hsp90N, a novel member of the Hsp90 family. Intriguingly, the ansamycin-binding domain is replaced in Hsp90N by a much shorter, hydrophobic...
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