Article
Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study.
The Journal of clinical endocrinology and metabolism - 1 Mar 2008
Elisei Rossella, Cosci Barbara, Romei Cristina, Bottici Valeria, Renzini Giulia, Molinaro Eleonora, Agate Laura, Vivaldi Agnese, Faviana Pinuccia, Basolo Fulvio, Miccoli Paolo, Berti Piero, Pacini Furio, Pinchera Aldo
Abstract excerpt
BACKGROUND: Medullary thyroid carcinoma (MTC) is a well-differentiated thyroid tumor that maintains the typical features of C cells. An advanced stage and the presence of lymph node metastases at diagnosis have been demonstrated to be the most important bad prognostic factors. Somatic RET mutations have been found in 40-50% of MTCs. Although a relationship between somatic mutations and bad prognosis has been...
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