Article
The prevalence of somatic RAS mutations in medullary thyroid cancer - a Polish population study.
Endokrynologia Polska - 1 Jan 2015
Oczko-Wojciechowska Malgorzata, Pfeifer Aleksandra, Rusinek Dagmara, Pawlaczek Agnieszka, Zebracka-Gala Jadwiga, Kowalska Malgorzata, Kowal Monika, Swierniak Michal, Krajewska Jolanta, Gawlik Tomasz, Chmielik Ewa, Czarniecka Agnieszka, Szpak-Ulczok Sylwia, Jarząb Barbara
Abstract excerpt
INTRODUCTION: Somatic RET mutations are detectable in two-thirds of sporadic cases of medullary thyroid cancer (MTC). Recent studies reported a high proportion of RAS somatic mutations in RET negative tumours, which may indicate RAS mutation as a possible alternative genetic event in sporadic MTC tumorigenesis. Thus, the aim of the study was to evaluate the frequency of somatic RAS mutations in sporadic medullary...
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