Article
Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer.
Cancer research - 1 Apr 2011
Butler Marcus W, Fukui Tomoya, Salit Jacqueline, Shaykhiev Renat, Mezey Jason G, Hackett Neil R, Crystal Ronald G
Abstract excerpt
The cathepsin inhibitor Cystatin A (CSTA) has antiapoptotic properties linked with neoplastic changes in squamous cell epithelium, where it has been proposed as a diagnostic and prognostic marker of lung cancer. Notably, cystatin A is upregulated in dysplastic epithelium, prompting us to hypothesize that it might be modulated in chronic obstructive pulmonary disease (COPD), a small airway epithelial (SAE)...
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