Article
A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis.
Allergy - 1 May 2007
Vasilopoulos Y, Cork M J, Teare D, Marinou I, Ward S J, Duff G W, Tazi-Ahnini R
Abstract excerpt
BACKGROUND: Cystatin A (CSTA) is a strong candidate for atopic dermatitis (AD) because it maps to AD susceptibility locus on chromosome 3q21 and it does inhibit Der p 1 and Der f 1, major house dust mite cysteine proteases and environmental triggers for AD and asthma. OBJECTIVE: To examine any association between polymorphisms in CSTA and AD and study the effect on the CSTA mRNA expression level. METHODS: We...
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