Article
Genetic variation in the alpha1B-adrenergic receptor and vascular response.
The pharmacogenomics journal - 1 Jul 2017
Adefurin A, Ghimire L V, Kohli U, Muszkat M, Sofowora G G, Li C, Levinson R T, Paranjape S Y, Stein C M, Kurnik D
Abstract excerpt
The alpha1B (α1B)-adrenergic receptors contribute to vasoconstriction in humans. We tested the hypothesis that variation in the ADRA1B gene contributes to interindividual variability and ethnic differences in adrenergic vasoconstriction. We measured dorsal hand vein responses to increasing doses of phenylephrine in 64 Caucasians and 41 African Americans and genotyped 34 ADRA1B variants. We validated findings in...
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