Article
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria.
Parasitology international - 1 Dec 2002
Omi Kazuya, Ohashi Jun, Patarapotikul Jintana, Hananantachai Hathairad, Naka Izumi, Looareesuwan Sornchai, Tokunaga Katsushi
Abstract excerpt
Human FcgammaRIIA and FcgammaRIIIB exhibit genetic polymorphisms, FcgammaRIIA-131H/R and FcgammaRIIIB-NA1/NA2, coding for different capacities for IgG binding and phagocytosis. Recently, FcgammaRIIA-131R was reported to be associated with protection against high-density Plasmodium falciparum infection in Kenya. Furthermore, FcgammaRIIIB-NA1/NA2 polymorphism was shown to influence FcgammaRIIA function in an...
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