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Article

Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2011

Piconese Silvia, Costanza Massimo, Musio Silvia, Tripodo Claudio, Poliani Pietro L, Gri Giorgia, Burocchi Alessia, Pittoni Paola, Gorzanelli Andrea, Colombo Mario P, Pedotti Rosetta

Abstract excerpt

Mast cell (MC)-deficient c-Kit mutant Kit(W/W-v) mice are protected against experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, suggesting a detrimental role for MCs in this disease. To further investigate the role of MCs in EAE, we took advantage of a recently characterized model of MC deficiency, Kit(W-sh/W-sh). Surprisingly, we observed that myelin oligodendrocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21321538
DOI: 10.1038/labinvest.2011.3

Genes

MOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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