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Article

Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1

8 Oct 2008

Abstract excerpt

Rad9 is conserved from yeast to humans and plays roles in DNA repair (homologous recombination repair, and base-pair excision repair) and cell cycle checkpoint controls. It has not previously been reported whether Rad9 is involved in DNA mismatch repair (MMR). In this study, we have demonstrated that both human and mouse Rad9 interacts physically with the MMR protein MLH1. Disruption of the interaction by a...

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PMID: 18842633
DOI: 10.1093/nar/gkn686

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