Article

Mice with <i>GNAO1</i> R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone

2019-06-06

Abstract excerpt

Neurodevelopmental disorder with involuntary movements (NEDIM, OMIM: 617493) is a severe, early onset neurological condition characterized by a delay in psychomotor development, hypotonia, and hyperkinetic involuntary movements. Heterozygous de novo mutations in the GNAO1 gene cause NEDIM. Gα o , the gene product of GNAO1, is the alpha subunit of G o , a member of the heterotrimeric G i/o family of G-protein...

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Literature Corpus work: 5a7e0fb2-9c5a-5c4f-8315-d93bd8bfb954
DOI: 10.1101/662031

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