Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseases.

Abstract excerpt

There is an increasing number of disease-associated Gα mutations identified from genome-wide sequencing campaigns or targeted efforts. Albright's Hereditary Osteodystrophy (AHO) was the first inherited disease associated with loss-of-function mutations in a G protein (Gαs) and other studies revealed gain-of-function Gα mutations in cancer. Here we attempted to solve the apparent quandary posed by the fact that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromogranins
• Share to GTP-Binding Protein alpha Subunits, Gi-Go