Article
Dual association of a TRKA polymorphism with schizophrenia.
Psychiatric genetics - 1 Jun 2011
Van Schijndel Jessica E, Van Zweeden Martine, Van Loo Karen M J, Djurovic Srdjan, Andreassen Ole A, Hansen Thomas, Werge Thomas, Nyegaard Mette, Sørensen Karina Meden, Nordentoft Merete, Mortensen Preben B, Mors Ole, Børglum Anders D, Del-Favero Jurgen, Norrback Karl-Fredrik, Adolfsson Rolf, De Hert Marc, Claes Stephan, Cichon Sven, Rietschel Marcella, Nöthen Markus M, Kallunki Pekka, Pedersen Jan T, Martens Gerard J M
Abstract excerpt
OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. METHODS: We genotyped the...
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