Article
Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia.
American journal of medical genetics - 8 Apr 2002
Hattori Mineko, Kunugi Hiroshi, Akahane Akihisa, Tanaka Hiroshi, Ishida Sugiko, Hirose Tetsuya, Morita Ryoji, Yamakawa Kazuhiro, Nanko Shinichiro
Abstract excerpt
Based on the neurodevelopmental hypothesis in the etiology of schizophrenia, neurotrophic factors may be involved in the pathogenesis of the illness. We searched for polymorphisms in the promoter region of the neurotrophin-3 (NTF3) gene by using denaturing high performance liquid chromatography (DHPLC). Six single nucleotide polymorphisms (SNPs) were found. When these polymorphisms were examined for association...
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