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Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA Translation

25 May 2010

Abstract excerpt

In up to 60% of human cancers, p53 gene mutations are responsible for direct inactivation of the tumor suppressor function of p53. Alternative mechanisms of p53 inactivation described thus far mainly affect its posttranslational regulation. In X-linked dyskeratosis congenita, a multisystemic syndrome characterized by increased cancer susceptibility, mutations of the DKC1 gene encoding dyskerin cause a selective...

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PMID: 20501855
DOI: 10.1158/0008-5472.can-09-4024

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