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Tetraploidy in normal tissues and diseases: mechanisms and consequences

21 Mar 2025

Abstract excerpt

Tetraploidisation plays a crucial role in evolution, development, stress adaptation, and disease, but its beneficial or pathological effects in different tissues remain unclear. This study aims to compare physiological and unphysiological tetraploidy in eight steps: 1) mechanisms of diploidy-to-tetraploidy transition, 2) induction and elimination of unphysiological tetraploidy, 3) tetraploid cell characteristics,...

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PMID: 40117022
DOI: 10.1007/s00412-025-00829-1

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