Article
A polymorphism in the angiotensin II type 1 receptor gene has different effects on the risk of diabetic nephropathy in men and women.
Molecular genetics and metabolism - 1 May 2011
Möllsten Anna, Vionnet Nathalie, Forsblom Carol, Parkkonen Maija, Tarnow Lise, Hadjadj Samy, Marre Michel, Parving Hans-Henrik, Groop Per-Henrik
Abstract excerpt
BACKGROUND: The etiology of diabetic nephropathy depends partly on genetic factors. Elevated systemic and intraglomerular blood pressure and glomerular filtration rate, partly regulated by the renin-angiotensin system, increase the risk of diabetic nephropathy. METHODS: The present case-control study investigated the association of the rs5186 polymorphism, in the angiotensin II type 1 receptor gene (AGTR1), with...
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