Article
Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.
Clinical biochemistry - 1 Jun 2010
Katerina Hirschfeldova, Michaela Sedova, Michal Vrablik, Helena Svobodova, Jana Zvarova, Jaroslav Hubacek, Richard Ceska
Abstract excerpt
OBJECTIVES: The aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels. DESIGN AND METHODS: We analysed 743 individuals (340 men and 403 women) with high mean triglyceride and LDL-c levels. The association of five polymorphic sites (ABCA1 g.1051G>A, APOA1 g.-75G>A, CETP g.-629C>A, HNF1A g.102A>C, and LIPG g.584C>T), apoE isoforms and...
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