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Article

Liver X receptor α gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study.

Pharmacogenetics and genomics - 1 Jun 2011

Price Elvin Tyrone, Pacanowski Michael A, Martin Michael A, Cooper-DeHoff Rhonda M, Pepine Carl J, Zineh Issam, Johnson Julie A

Abstract excerpt

BACKGROUND/AIMS: Liver X receptor-α (LXRA) is a nuclear receptor that regulates genes important in cholesterol homeostasis and inflammation. Several single nucleotide polymorphisms (SNPs) in the LXRA gene (NR1H3) have been earlier associated with metabolic phenotypes (dyslipidemia and elevated body mass index). Metabolic dysregulation is a major contributor to coronary disease; therefore, we assessed LXRA in...

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Identifiers

PMID: 21562465
DOI: 10.1097/FPC.0b013e3283452fec
PMCID: PMC3093636

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