Article
Prenatal TCDD causes persistent modulation of the postnatal immune response, and exacerbates inflammatory disease, in 36-week-old lupus-like autoimmune SNF1 mice.
Birth defects research. Part B, Developmental and reproductive toxicology - 1 Feb 2011
Mustafa Amjad, Holladay Steven, Witonsky Sharon, Zimmerman Kurt, Manari Ashley, Countermarsh Sheryl, Karpuzoglu Ebru, Gogal Robert
Abstract excerpt
BACKGROUND: Prenatal exposure to the persistent environmental pollutant and model Ah receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has been shown to permanently suppress postnatal cell-mediated immunity. More recently, skewing of select adult T and B cell responses toward enhanced inflammation has also been described in C57BL/6 mice after prenatal TCDD. This raises questions about adverse...
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