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Article

Implications of tioguanine dosing in IBD patients with a TPMT deficiency

2023-01-23

Abstract excerpt

<h4>Purpose: </h4> Tioguanine is metabolised by less enzymatic steps compared to azathioprine and mercaptopurine, without generating 6-methylmercaptopurine ribonucleotides. However, thiopurine S-methyl transferase (TPMT) plays a role in early toxicity in all thiopurines. We aimed to describe the hazards and opportunities of tioguanine use in inflammatory bowel disease (IBD) patients with aberrant TPMT metabolism a...

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Literature Corpus work
6f4358c4-e115-505c-a442-abd0e5e5f267
DOI
10.21203/rs.3.rs-2492040/v1
Open publication

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Implications of tioguanine dosing in IBD patients with a TPMT deficiencyDOI 10.21203/rs.3.rs-2492040/v1
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