Article
Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
Inflammatory bowel diseases - 29 Nov 2018
Roberts Rebecca L, Wallace Mary C, Seinen Margien L, van Bodegraven Adriaan A, Krishnaprasad Krupa, Jones Gregory T, van Rij Andre M, Baird Angela, Lawrance Ian C, Prosser Ruth, Bampton Peter, Grafton Rachel, Simms Lisa A, Studd Corrie, Bell Sally J, Kennedy Martin A, Halliwell Jacob, Gearry Richard B, Radford-Smith Graham, Andrews Jane M, McHugh Patrick C, Barclay Murray L
Abstract excerpt
Background: Up to 20% of patients with inflammatory bowel disease (IBD) who are refractory to thiopurine therapy preferentially produce 6-methylmercaptopurine (6-MMP) at the expense of 6-thioguanine nucleotides (6-TGN), resulting in a high 6-MMP:6-TGN ratio (>20). The objective of this study was to evaluate whether genetic variability in guanine monophosphate synthetase (GMPS) contributes to preferential 6-MMP...
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