Article
Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.
Clinica chimica acta; international journal of clinical chemistry - 12 May 2011
Lau Kin-Chong, Lam Ching-Wan, Law Chun-Yiu, Lai Sik-To, Tsang Tak-Yin, Siu Carol Wai-Kwan, To Wing-Kin, Leung Ka-Fai, Mak Chloe Miu, Poon Wing-Tat, Chan Paul Kay-Sheung, Chan Yan-Wo
Abstract excerpt
BACKGROUND: Polymorphisms in the major histocompatibility complex (MHC) and non-MHC genes were recently reported to be associated with persistent hepatitis B virus (HBV) infection and host response to hepatitis B vaccine in Asian populations. We aimed to confirm the associations in Chinese population and develop a non-invasive screening method for the risk loci. METHODS: We genotyped 2 risk alleles on the MHC...
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