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Article

Generation of two modified mouse alleles of the Hic1 tumor suppressor gene.

Genesis (New York, N.Y. : 2000) - 1 Mar 2011

Pospichalova Vendula, Tureckova Jolana, Fafilek Bohumil, Vojtechova Martina, Krausova Michaela, Lukas Jan, Sloncova Eva, Takacova Sylvia, Divoky Vladimir, Leprince Dominique, Plachy Jiri, Korinek Vladimir

Abstract excerpt

HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene located on chromosome 17p13.3, a region frequently hypermethylated or deleted in human neoplasias. In mouse, Hic1 is essential for embryonic development and exerts an antitumor role in adult animals. Since Hic1-deficient mice die perinatally, we generated a conditional Hic1 null allele by flanking the Hic1-coding region by loxP sites. When crossed to...

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Source

Identifiers

PMID: 21309068
DOI: 10.1002/dvg.20719

Genes

HIC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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