Article
Association of IL-13 polymorphisms with leukotriene receptor antagonist drug responsiveness in Korean children with exercise-induced bronchoconstriction.
Pharmacogenetics and genomics - 1 Jul 2008
Kang Mi-Jin, Lee So-Yeon, Kim Hyo-Bin, Yu Jinho, Kim Byoung-Ju, Choi Won-Ah, Jang Seong-Ok, Hong Soo-Jong
Abstract excerpt
BACKGROUND: IL-13 is a pivotal cytokine in allergic inflammation and bronchial hyperresponsiveness, and is known to influence leukotriene levels. OBJECTIVE: We investigated whether IL-13 polymorphisms may be associated with clinical phenotypes and drug responsiveness to the leukotriene receptor antagonist (LTRA) in Korean asthmatic children with exercise-induced bronchoconstriction (EIB). METHODS: We enrolled 242...
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