Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism.

doi:10.1210/jc.2010-2455

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Article

Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism.

The Journal of clinical endocrinology and metabolism - 1 May 2011

Delgado-Lista Javier, Garcia-Rios Antonio, Perez-Martinez Pablo, Solivera Juan, Yubero-Serrano Elena M, Fuentes Francisco, Parnell Laurence D, Shen Jian, Gomez Purificacion, Jimenez-Gomez Yolanda, Gomez-Luna Maria J, Marin Carmen, Belisle Sarah E, Rodriguez-Cantalejo Fernando, Meydani Simin N, Ordovas Jose M, Perez-Jimenez Francisco, Lopez-Miranda Jose

Abstract excerpt

CONTEXT: IL1b (IL1B or IL1β), a key modulator of the immune response, exerts its functions mainly via IL6 regulation. Fatty meals cause transient hypertriglyceridemia and are considered to be proinflammatory, but the extent of these responses shows high interindividual susceptibility. OBJECTIVE: We evaluated the influence of a genetic variant located in the promoter region of IL1B (-1473G/C) on fasting and...

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Identifiers

PMID: 21307135
DOI: 10.1210/jc.2010-2455
PMCID: PMC3085209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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