Article
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
Human molecular genetics - 1 May 2011
Khor Chiea Chuen, Ramdas Wishal D, Vithana Eranga N, Cornes Belinda K, Sim Xueling, Tay Wan-Ting, Saw Seang-Mei, Zheng Yingfeng, Lavanya Raghavan, Wu Renyi, Wang Jie Jin, Mitchell Paul, Uitterlinden André G, Rivadeneira Fernando, Teo Yik-Ying, Chia Kee-Seng, Seielstad Mark, Hibberd Martin, Vingerling Johannes R, Klaver Caroline C W, Jansonius Nomdo M, Tai E-Shyong, Wong Tien-Yin, van Duijn Cornelia M, Aung Tin
Abstract excerpt
Damage to the optic nerve (e.g. from glaucoma) has an adverse and often irreversible impact on vision. Earlier studies have suggested that the size of the optic nerve head could be governed by hereditary factors. We conducted a genome-wide association study (GWAS) on 4445 Singaporean individuals (n = 2132 of Indian and n = 2313 of Malay ancestry, respectively), with replication in Rotterdam, the Netherlands (n =...
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