Article
Common genetic variants associated with open-angle glaucoma.
Human molecular genetics - 15 Jun 2011
Ramdas Wishal D, van Koolwijk Leonieke M E, Lemij Hans G, Pasutto Francesca, Cree Angela J, Thorleifsson Gudmar, Janssen Sarah F, Jacoline Ten Brink, Amin Najaf, Rivadeneira Fernando, Wolfs Roger C W, Walters G Bragi, Jonasson Fridbert, Weisschuh Nicole, Mardin Christian Y, Gibson Jane, Zegers Richard H C, Hofman Albert, de Jong Paulus T V M, Uitterlinden André G, Oostra Ben A, Thorsteinsdottir Unnur, Gramer Eugen, Welgen-Lüssen Ulrich C, Kirwan James F, Bergen Arthur A B, Reis André, Stefansson Kari, Lotery Andrew J, Vingerling Johannes R, Jansonius Nomdo M, Klaver Caroline C W, van Duijn Cornelia M
Abstract excerpt
Open-angle glaucoma (glaucoma) is a major eye disorder characterized by optic disc pathology. Recent genome-wide association studies identified new loci associated with clinically relevant optic disc parameters, such as the optic disc area and vertical cup-disc ratio (VCDR). We examined to what extent these loci are involved in glaucoma. The loci studied include ATOH7, CDC7/TGFBR3 and SALL1 for optic disc area,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.