Article
Association study of MC4R with complex obesity and replication of the rs17782313 association signal.
Molecular genetics and metabolism - 1 May 2011
Beckers Sigri, Zegers Doreen, de Freitas Fenna, Mertens Ilse L, Van Gaal Luc F, Van Hul Wim
Abstract excerpt
Recently, genome-wide association studies have discovered several single nucleotide polymorphisms (SNPs) involved in the etiology of complex obesity. A variant downstream from the melanocortin-4 receptor gene (MC4R), a gene known to be involved in monogenic obesity, was reported to be highly associated with BMI. In the present study, we performed a replication study with the previously reported SNP rs17782313. We...
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