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Article

Common melanocortin-3 receptor variants are not associated with obesity, although rs3746619 does influence weight in obese individuals.

Endocrine - 1 Oct 2010

Zegers Doreen, Beckers Sigri, Mertens Ilse L, Van Gaal Luc F, Van Hul Wim

Abstract excerpt

The melanocortin-3 receptor is a vital link in the leptin-melanocortin signaling pathway in the brain and has a role in the regulation of energy homeostasis. It was hypothesized that common polymorphisms in MC3R could increase susceptibility for the development of obesity, but different studies have led to contradictory results. In this study, we investigated the association of SNPs in MC3R with the development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptor, Melanocortin, Type 3

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Identifiers

PMID: 20972733
DOI: 10.1007/s12020-010-9386-5

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