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Article

Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype.

Veterinary parasitology - 22 Mar 2011

Bourguinat Catherine, Keller Kathy, Blagburn Byron, Schenker Rudolf, Geary Timothy G, Prichard Roger K

Abstract excerpt

Macrocyclic lactone (ML) molecules have been used for heartworm control for more than 25 years. However, in recent years, there have been reports of loss of efficacy of ML heartworm preventatives against Dirofilaria immitis in some locations in the United States. Macrocyclic lactone resistance is a common problem in nematode parasites of livestock, and more recently, evidence of ivermectin resistance has been...

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Identifiers

PMID: 21300438
DOI: 10.1016/j.vetpar.2011.01.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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