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Article

Laboratory assays reveal diverse phenotypes among microfilariae of Dirofilaria immitis isolates with known macrocyclic lactone susceptibility status.

PloS one - 1 Jan 2020

Jesudoss Chelladurai Jeba R J, Martin Katy A, Chinchilla-Vargas Krystal, Jimenez Castro Pablo D, Kaplan Ray M, Brewer Matthew T

Abstract excerpt

Prevention of canine heartworm disease caused by Dirofilaria immitis relies on chemoprophylaxis with macrocyclic lactone anthelmintics. Alarmingly, there are increased reports of D. immitis isolates with resistance to macrocyclic lactones and the ability to break through prophylaxis. Yet, there is not a well-established laboratory assay that can utilize biochemical phenotypes of microfilariae to predict drug...

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PMID: 32760111
DOI: 10.1371/journal.pone.0237150
PMCID: PMC7410292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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