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Article

Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.

Human genetics - 1 Jun 2011

Minear Mollie A, Crosslin David R, Sutton Beth S, Connelly Jessica J, Nelson Sarah C, Gadson-Watson Shera, Wang Tianyuan, Seo David, Vance Jeffrey M, Sketch Michael H, Haynes Carol, Goldschmidt-Clermont Pascal J, Shah Svati H, Kraus William E, Hauser Elizabeth R, Gregory Simon G

Abstract excerpt

Tenascin-C (TNC) is an extracellular matrix protein implicated in biological processes important for atherosclerotic plaque development and progression, including smooth muscle cell migration and proliferation. Previously, we observed differential expression of TNC in atherosclerotic aortas compared with healthy aortas. The goal of this study was to investigate whether common genetic variation within TNC is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21298289
DOI: 10.1007/s00439-011-0959-z
PMCID: PMC3576662

Genes

TNC
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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