Article
Presence and transmission of mitochondrial heteroplasmic mutations in human populations of European and African ancestry.
Mitochondrion - 1 Sept 2021
Liu Chunyu, Fetterman Jessica L, Qian Yong, Sun Xianbang, Blackwell Thomas W, Pitsillides Achilleas, Cade Brian E, Wang Heming, Raffield Laura M, Lange Leslie A, Anugu Pramod, Abecasis Goncalo, Adrienne Cupples L, Redline Susan, Correa Adolfo, Vasan Ramachandran S, Wilson James G, Ding Jun, Levy Daniel
Abstract excerpt
We investigated the concordance of mitochondrial DNA heteroplasmic mutations (heteroplasmies) in 6745 maternal pairs of European (EA, n = 4718 pairs) and African (AA, n = 2027 pairs) Americans in whole blood. Mother-offspring pairs displayed the highest concordance rate, followed by sibling-sibling and more distantly-related maternal pairs. The allele fractions of concordant heteroplasmies exhibited high...
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