Article
Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes.
Arthritis research - 1 Jan 2000
Tan L C, Mowat A G, Fazou C, Rostron T, Roskell H, Dunbar P R, Tournay C, Romagné F, Peyrat M A, Houssaint E, Bonneville M, Rickinson A B, McMichael A J, Callan M F
Abstract excerpt
INTRODUCTION: Epstein-Barr virus (EBV) is transmitted orally, replicates in the oropharynx and establishes life-long latency in human B lymphocytes. T-cell responses to latent and lytic/replicative cycle proteins are readily detectable in peripheral blood from healthy EBV-seropositive individuals. EBV has also been detected within synovial tissue, and T-cell responses to EBV lytic proteins have been reported in...
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