Article
Allorecognition and T cell repertoire selection in severe combined immunodeficiency lacking HLA class II antigens.
Transplantation - 1 Jun 1992
Knobloch C, Ballas M, Wölpl A, Friedrich W
Abstract excerpt
In order to elucidate the role of HLA class II molecules in generation of self-nonself discrimination of human T cells, we have analyzed T cell functions in an HLA class II-negative severe combined immunodeficiency patient. Patient PBL expressed no HLA-DR, -DQ, and -DP antigens as judged by immunofluorescence using mAb, and failed to elicit MLR responses from unrelated controls. Patient PBL contained mature T...
Topics
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- CD3 Complex
- CD4 Antigens
- Child, Preschool
- Female
- Genotype
- HLA-DR Antigens
- Histocompatibility Antigens Class II
- Humans
- Molecular Sequence Data