Capillary dried blood microsampling is not suited for dihydropyrimidine dehydrogenase (DPD) phenotyping.

doi:10.1515/cclm-2026-0146

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Article

Capillary dried blood microsampling is not suited for dihydropyrimidine dehydrogenase (DPD) phenotyping.

Clinical chemistry and laboratory medicine - 25 Sept 2026

Vandenbroucke Kevin, Stepman Hedwig, Stove Christophe

Abstract excerpt

OBJECTIVES: Dihydropyrimidine dehydrogenase (DPD) phenotyping through uracil and dihydrouracil determination is a well-established approach to identify (partial) DPD deficiencies prior to fluoropyrimidine chemotherapy. However, preanalytical stability has challenged this test for years. This study therefore investigated whether dried blood spots (DBS) can improve preanalytical stability. METHODS: Uracil,...

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PMID: 42083890
DOI: 10.1515/cclm-2026-0146

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