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Article

IL7Rα contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2013

Ashbaugh Jessica J, Brambilla Roberta, Karmally Shaffiat A, Cabello Cecilia, Malek Thomas R, Bethea John R

Abstract excerpt

A mutation in the IL7Rα locus has been identified as a risk factor for multiple sclerosis (MS), a neurodegenerative autoimmune disease characterized by inflammation, demyelination, and axonal damage. IL7Rα has well documented roles in lymphocyte development and homeostasis, but its involvement in disease is largely understudied. In this study, we use the experimental autoimmune encephalomyelitis (EAE) model of MS...

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Source

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Identifiers

PMID: 23530149
DOI: 10.4049/jimmunol.1203214
PMCID: PMC4120889

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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