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Article

A quality control program for mutation detection in KIT and PDGFRA in gastrointestinal stromal tumours.

Journal of gastroenterology - 1 May 2011

Hostein Isabelle, Debiec-Rychter Maria, Olschwang Sylvianne, Bringuier Pierre-Paul, Toffolati Louisa, Gonzalez David, Forget Sébastien, Escande Fabienne, Morzuch Lucyna, Tamborini Elena, Faur Nicolas, Pilotti Silvana, Dei Tos Paolo, Emile Jean-François, Coindre Jean-Michel

Abstract excerpt

BACKGROUND: Although most gastrointestinal stromal tumours (GIST) carry oncogenic mutations in KIT exons 9, 11, 13 and 17, or in platelet-derived growth factor receptor alpha (PDGFRA) exons 12, 14 and 18, around 10% of GIST are free of these mutations. Genotyping and accurate detection of KIT/PDGFRA mutations in GIST are becoming increasingly useful for clinicians in the management of the disease. METHOD: To...

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Source

Identifiers

PMID: 21286759
DOI: 10.1007/s00535-011-0375-0

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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