Article
Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors.
BMC medical genetics - 4 Jul 2010
Merkelbach-Bruse Sabine, Dietmaier Wolfgang, Füzesi Laszlo, Gaumann Andreas, Haller Florian, Kitz Julia, Krohn Antje, Mechtersheimer Gunhild, Penzel Roland, Schildhaus Hans-Ulrich, Schneider-Stock Regine, Simon Ronald, Wardelmann Eva
Abstract excerpt
BACKGROUND: Mutation analysis of KIT and PDGFRA genes in gastrointestinal stromal tumors is gaining increasing importance for prognosis of GISTs and for prediction of treatment response. Several groups have identified specific mutational subtypes in KIT exon 11 associated with an increased risk of metastatic disease whereas GISTs with PDGFRA mutations often behave less aggressive. Furthermore, in advanced GIST...
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