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Article

Mutational analysis of gastrointestinal stromal tumors (GISTs): procedural approach for diagnostic purposes.

Cancer genomics & proteomics - 1 Jan 2000

Palmirotta Raffaele, De Marchis Maria Laura, Ludovici Giorgia, Leone Barbara, Covello Renato, Conti Salvatore, Costarelli Leopoldo, Della-Morte David, Ferroni Patrizia, Roselli Mario, Guadagni Fiorella

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract characterized, in the majority of cases, by activating mutations in the KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) or PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) genes. Mutations affecting these tyrosine kinase receptors are also responsible for the...

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PMID: 23741027

Genes

KIT
PDGFRA

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