Anterior Segment Dysgenesis and Early-Onset Glaucoma in<i>nee</i>Mice with Mutation of<i>Sh3pxd2b</i>

Abstract excerpt

PURPOSE: Mutations in SH3PXD2B cause Frank-Ter Haar syndrome, a rare condition characterized by congenital glaucoma, as well as craniofacial, skeletal, and cardiac anomalies. The nee strain of mice carries a spontaneously arising mutation in Sh3pxd2b. The purpose of this study was to test whether nee mice develop glaucoma. METHODS: Eyes of nee mutants and strain-matched controls were comparatively analyzed at...

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