Article
Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.
Diabetes - 1 Mar 2011
De Silva N Maneka G, Freathy Rachel M, Palmer Tom M, Donnelly Louise A, Luan Jian'an, Gaunt Tom, Langenberg Claudia, Weedon Michael N, Shields Beverley, Knight Beatrice A, Ward Kirsten J, Sandhu Manjinder S, Harbord Roger M, McCarthy Mark I, Smith George Davey, Ebrahim Shah, Hattersley Andrew T, Wareham Nicholas, Lawlor Debbie A, Morris Andrew D, Palmer Colin N A, Frayling Timothy M
Abstract excerpt
OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally influence the risk of type 2 diabetes and raise normal fasting glucose levels and hepatic insulin resistance. RESEARCH DESIGN AND METHODS: We tested 10 common genetic...
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